background medicinal plants are believed to be important sources of new chemical substances with potential therapeutic effects. washingtonia filifera is characterized by its high content of flavonoids. numerous studies suggest that flavonoids have potential for the prevention and treatment of several diseases. objectives this study aimed to investigate the anti-inflammatory activity of the wash...

objective(s):recently anti-inflammatory effects of antidepressants have been demonstrated. venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. the pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. anti-inflammatory effects of venlafaxine a...

Inflammatory disorders alone or as a consequence of neurological disease affecting patients in life. Experimental models of inflammation are use to evaluate the production of inflammatory mediators at site of inflammation. Curcumin is one of the flavonoids possesses potent anti-inflammatory activity. However, because of low water solubility curcumin, its clinical application has been limited. T...

Background: Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and inflammation conditions. Methods: Animals were divided as follows: control group, carrageenan and chronic morphine recipients, acute morphine recip...

Abstract Carrageenan is used widely in food products especially for gelling, thickening, emulsifying agents, and to stabilize the properties which extracted from red purple seaweeds that contain mixture of polysaccharides. Based on sulfate content, carrageenan divided as kappa-carrageenan, iota-carrageenan, lambda carrageenan. Even though it industry, there controversy about health effects usin...

The adipose tissue-derived protein, adiponectin, has significant anti-inflammatory properties in a variety of disease conditions. Recent evidence that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in central nervous system, suggests that it may also have a central modulatory role in pain and inflammation. This study set out to investigate the effects of exogenously applied r...

The common food additive carrageenan is a known activator of inflammation in mammalian tissues and stimulates both the canonical and noncanonical pathways of NF-κB activation. Exposure to low concentrations of carrageenan (10 μ g/mL in the water supply) has produced glucose intolerance, insulin resistance, and impaired insulin signaling in C57BL/6 mice. B-cell leukemia/lymphoma 10 (Bcl10) is a ...

BACKGROUND Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nociceptors. Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators. However, the role of ASIC3 in inflammation remains inconclusive because of conflicting results generated from studies of ...

BACKGROUND Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an "unhealthy" state such as that during bacterial infection or acute inflammation, carrageenan can synergistically enhance the inflammatory response. METHODS BALB/...

Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of...